The following players won their first Grand Slam title at Roland Garros and during the tournament (up to the final or in the final) they beat the number 1 seeded player:
Henri Cochet (1926 Vincent Richards)
Henner Henkel (1937 Henry W. Austin)
Don McNeill (1939 Bobby Riggs)
Marcel Bernard (1946 Yvon Petra)
Asbóth József (1947 Tom Brown)
Budge Patty (1950 Jaroslav Drobny)
Jaroslav Drobny (1951 Frank Sedgman)
Manuel Santana (1961 Nicola Pietrangeli)
Adriano Panatta (1976 Bjorn Borg)
Ivan Lendl (1984 John McEnroe)
Michael Chang (1989 Ivan Lendl)
Jim Courier (1991 Stefan Edberg)
Sergi Bruguera (1993 Pete Sampras)
Yevgeny Kafelnikov (1996 Pete Sampras)
Rafael Nadal (2005 Roger Federer)